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An application of Aggregate Exposure Pathway and Adverse Outcome Pathway frameworks to facilitate the integration of human health and ecological endpoints for Cumulative Risk Assessment
Citation:
Hines, D., R. Conolly, AND A. Jarabek. An application of Aggregate Exposure Pathway and Adverse Outcome Pathway frameworks to facilitate the integration of human health and ecological endpoints for Cumulative Risk Assessment. RTI, Durham, North Carolina, October 30, 2018.
Impact/Purpose:
This work expands a previous case study, which focused on integration of toxicity mechanisms using the Adverse Outcome Pathway (AOP) for a data rich chemical (perchlorate anion, ClO4-), and suggested linking this toxicity data to a hypothetical exposure model to demonstrate a quantitative source-to-outcome approach. Here, we extend the AOP component to do that by developing the Aggregate Exposure Pathway component using a fate and transport model to represent the movement of this chemical through a hypothetical wetland. We quantitatively describe external exposure under three different hypothetical contamination scenarios for humans, small mammals, and fishes. We then apply previously published, species-specific Physiologically Based Pharmacokinetic (PBPK) models to link external exposure predictions to internal exposure in these three groups of organisms, and demonstrate how these predictions, along with the integrated AEP and AOP frameworks, can inform a comprehensive source-to-outcome approach to CRA that includes both human health and ecological endpoints together.
Description:
This is a presentation that will be given as a seminar at RTI