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Think Tank of Quality Assurance & Quality Control for Untargeted Metabolomic Studies
Citation:
Bandukwala, A., D. Bearden, R. Beger, B. Bethan, D. Broadhurst, D. Carrick, P. Chen, C. Clish, D. Daee, S. Dasari, L. Derr, W. Dunn, A. Evans, S. Fischer, T. Flynn, J. Harnly, T. Hartung, D. Herrington, R. Higashi, P. Hsu, J. Huang, C. Jones, M. Kachman, H. Karuso, G. Kruppa, T. Layne, K. Lippa, E. Loftfield, P. Maruvada, J. Mosley, I. Ntai, C. O'Donovan, M. Playdon, R. Plumb, D. Raftery, D. Shaughnessy, A. Souza, T. Spaeder, B. Spa/holz, S. Sumner, F. Tayyari, B. Ubhi, M. Verma, T. Walk, I. Wilson, K. Witkin, AND K. Zanetti. Think Tank of Quality Assurance & Quality Control for Untargeted Metabolomic Studies. Metabolomics 2018, Seattle, WA, June 24 - 28, 2018.
Impact/Purpose:
The Metabolomics Quality Assurance and quality Control Consortium (mQACC) is a community-led effort to strengthen quality assurance (QA) and quality control (QC) practices for untargeted metabolomics research and reporting. The mQACC's objectives are to: Identify the most useful metrics for assessing study and data quality for untargeted metabolomic studies.
Description:
The Metabolomics Quality Assurance and quality Control Consortium (mQACC) is a community-led effort to strengthen quality assurance (QA) and quality control (QC) practices for untargeted metabolomics research and reporting. mQACC was established through an inaugural meeting, funded by the National Institutes of Health, held in October 2017. Data from a survey published by Dunn, et al. (Metabolomics, 2017) was used to establish meeting objectives: 1.) Identify the most useful metrics for assessing data quality for untargeted metabolomic studies; 2.) identify and prioritize processes to ensure appropriate reporting of QA/QC data; and 3.) identify and prioritize the types of test materials that are needed in the field of metabolomics for QA/QC in untargeted studies. Key priorities for each meeting objective were identified and scored for importance, resulting in several primary themes. Although priorities were identified for long-term efforts, three immediate priorities were moved forward: 1.) prepare a meeting report for publication; 2.) prepare a manuscript documenting the complete experimental procedure for untargeted metabolomics, including the QC practices; and 3.) identify reference materials that need to be developed quickly. mQACC currently includes over 40 representatives from the United States, Europe, and Asia, including instrument manufacturers, commercial laboratories, and government and academic stakeholders. The consortium has continued to be active since the inaugural meeting, holding monthly teleconferences and establishing working groups to address these initial priorities. In addition to describing the mQACC priorities, we will highlight how the metabolomics community can get involved in this important effort.
