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Computer modeling and simulation to reconstruct the basis of developmental toxicity
Citation:
Knudsen, T. Computer modeling and simulation to reconstruct the basis of developmental toxicity. Presented at 3rd Annual Predict:3D Models Summit, Boston, MA, August 21 - 23, 2018. https://doi.org/10.23645/epacomptox.7157024
Impact/Purpose:
Presentation to Predict:3D Models Annual Summit August 2018
Description:
The 2016 amendment of the Toxic Substance Control Act mandated that the EPA must accelerate development of scientifically valid test methods to prioritize large numbers of chemicals with less reliance on animal testing. ‘Advancing actionable alternatives to vertebrate animal testing for chemical safety assessment’ requires in vitro data and in silico models for complex processes. Computer modeling and simulation is uniquely positioned to translate data from in vitro cell and tissue models into higher-order topologies predicted for complex systems.
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DOI: Computer modeling and simulation to reconstruct the basis of developmental toxicity
3D_SUMMIT_BOSTON_2018_V2_M.PDF (PDF, NA pp, 3675.495 KB, about PDF)