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Advancing the Adverse Outcome Pathway Framework – An International Horizon Scanning Approach
Citation:
Conolly, R. AND M. Hecker. Advancing the Adverse Outcome Pathway Framework – An International Horizon Scanning Approach. SOT Annual Meeting, San Antonio, Texas, March 11 - 15, 2018.
Impact/Purpose:
This is the overview abstract for a proposed Workshop at the 2018 Annual Meeting of the Society of Toxicology in San Antonio, March 11 - 15, 2018. The proposed workshop will describe and elaborate on the results of a "Horizon-Scanning" survey that was conducted to solicit questions from the global scientific and regulatory communities, including the SOT community, concerning the perceived challenges and/or limitations that must be addressed to realize the full potential of the adverse outcome pathway (AOP) framework in research and regulatory decision-making. Questions submitted from all sectors and from across the globe were used to identify key themes that, if addressed, would significantly advance development and application of the AOP framework. Following this exercise, a Society of Environmental Toxicology & Chemistry (SETAC) Pellston™ Workshop comprised of international participants representing industry, government, academia, and Non-Governmental Organizations was held in Cornwall, Ontario, in April 2017 to begin exploring these themes and answering associated key questions. The proposed SOT workshop is intended to serve as a podium to present the outcomes of the Horizon Scanning exercise and of the Pellston™ Workshop and to foster discussion with SOT members in order to continue advancing the AOP framework. Specifically, presentations will cover topics including the development and application of AOP networks, quantitative AOPs and associated modeling approaches, and the status of and future needs for application of the framework in regulatory decision making. Furthermore, talks will explore a roadmap to enhance awareness of, involvement in, and acceptance of the AOP framework by regulatory agencies, scientists, and other stakeholder groups. Presentations will review frequently asked questions identified during horizon scanning and address common misunderstandings pertaining to the AOP framework. Finally, the audience will be asked to participate in a panel discussion following the presentations to build upon ideas and outcomes derived from the SETAC Pellston™ Workshop.
Description:
In 2007, the U.S. National Research Council laid out a vision and strategy for toxicity testing in the 21st century, which aspired to transform current testing approaches by making greater use of recent scientific advances in cell-based and computational methods. The adverse outcome pathway (AOP) framework, which has emerged to address this vision, has since gained international traction as a systematic approach for capturing existing knowledge to transparently link mechanistic data to apical toxicity endpoints as a means to inform research and risk assessment. While the framework has evolved significantly since its introduction in 2010, it was recognized that a survey of the broader scientific community would be useful in identifying challenges and in guiding future initiatives. To that end, a Horizon Scanning exercise was conducted to solicit questions from the global scientific and regulatory communities, including the SOT community, concerning the perceived challenges and/or limitations that must be addressed to realize the full potential of the AOP framework in research and regulatory decision-making. Questions submitted from all sectors and from across the globe were used to identify key themes that, if addressed, would significantly advance development and application of the AOP framework. Following this exercise, a Society of Environmental Toxicology & Chemistry (SETAC) Pellston™ Workshop comprised of international participants representing industry, government, academia, and Non-Governmental Organizations was held in Cornwall, Ontario, in April 2017 to begin exploring these themes and answering associated key questions. The current session serves as a podium to present the outcomes of the Horizon Scanning exercise and of the Pellston™ Workshop and to foster discussion with SOT members in order to continue advancing the AOP framework. Specifically, presentations will cover topics including the development and application of AOP networks, quantitative AOPs and associated modeling approaches, and the status of and future needs for application of the framework in regulatory decision making. Furthermore, talks will explore a roadmap to enhance awareness of, involvement in, and acceptance of the AOP framework by regulatory agencies, scientists, and other stakeholder groups. Presentations will review frequently asked questions identified during horizon scanning and address common misunderstandings pertaining to the AOP framework. Finally, the audience will be asked to participate in a panel discussion following the presentations to build upon ideas and outcomes derived from the SETAC Pellston™ Workshop. This abstract does not necessarily reflect any specific policy of the U.S. EPA