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Exposure-based Chemical Priority Setting in the 21st Century
Citation:
Wambaugh, J. Exposure-based Chemical Priority Setting in the 21st Century. Presented at Duke Risk Assessment Course, NC, Durham, February 12, 2018. https://doi.org/10.23645/epacomptox.7098581
Impact/Purpose:
This presentation is one half of a lecture to the Duke Risk Assessment course. Katie Paul-Friedman will be presenting on ToxCast, while this presentation broadly covers ExpoCast.
Description:
The EPA protects human and environmental health by characterizing potential risks from chemical exposures. To facilitate evaluations for the thousands of commercial and environmental chemicals, suites of in vitro high-throughput screening (HTS) assays have been employed as a first tier screening tool, as in the U.S. Federal Tox21 consortium and the U.S. EPA Toxicity Forecaster (ToxCast) program. In tandem with ToxCast, the Exposure Forecaster (ExpoCast) program provides toxicokinetic (TK) data and exposure estimates to provide context for HTS data. This includes new analyses of existing biomonitoring data, and generation of new data using in vitro technologies and non-targeted chemical analysis (NTA). These new tools aim to provide the toxicological, exposure, and dosimetry data necessary for chemical safety decisions. The views expressed here are those of the author and do not necessarily reflect the views or policies of the U. S. EPA.
URLs/Downloads:
DOI: Exposure-based Chemical Priority Setting in the 21st Century
DUKE-WAMBAUGH-021218.PDF (PDF, NA pp, 5225.411 KB, about PDF)