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Exposure Based Priority Setting for Chemical Safety
Citation:
Wambaugh, J. Exposure Based Priority Setting for Chemical Safety. Presented at NCSU Bioinformatics Research Center Seminar, Raleigh, NC, January 10, 2018. https://doi.org/10.23645/epacomptox.7073096
Impact/Purpose:
Presentation to NCSU Bioinformatics Research Center, January 10, 2018
Description:
We would like to know more about the risk posed by thousands of chemicals in the environment – which ones should we start with? High throughput screening (HTS) provides a path forward for identifying potential hazard, but the real world is full of more mixtures than we can test. Exposure-based priority setting allows identification of the most relevant mixtures. New informatic tools are needed to analyze complex data characterizing human exposure. New analytical chemistry tools (i.e., non-targeted analysis or NTA) are needed to develop the data to understand to what and how we are expose. These NTA tools present their own informatics challenges. Finally, using in vitro methods developed for pharmaceuticals, we can relatively efficiently predict TK for large numbers of chemicals, but we are limited by analytical chemistry.
URLs/Downloads:
DOI: Exposure Based Priority Setting for Chemical Safety
NCSU-BIOINFORMATICS-WAMBAUGH-011018-2.PDF (PDF, NA pp, 5870.72 KB, about PDF)