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Use of the ToxCast and Tox21 Screening Strategies in Support of Chemical Prioritization for Risk Assessment
Citation:
Houck, K. Use of the ToxCast and Tox21 Screening Strategies in Support of Chemical Prioritization for Risk Assessment. Presented at Presentation at Wageningen University June 2018, Wageningen, N/A, NETHERLANDS, June 18, 2018. https://doi.org/10.23645/epacomptox.7001291
Impact/Purpose:
Invited Talk at Wageningen University the Netherlands June 2018
Description:
What is new with the ToxCast Strategy? Nuclear receptor multispecies screening, high-throughput transcriptomics, phenotypic screening cell painting assay, and use of metabolic activation systems in vitro. In vitro/alternative approaches are valuable for chemical prioritization, especially where we understand the toxicity pathways. May also be useful in conservative point-of-departure approaches for unknown/non-selective effects. Combining these new strategies with exposure predictions allows prioritization for risk assessment.
URLs/Downloads:
DOI: Use of the ToxCast and Tox21 Screening Strategies in Support of Chemical Prioritization for Risk Assessment
WU__HOUCK_1028_V2_M.PDF (PDF, NA pp, 6839.529 KB, about PDF)