You are here:
High-throughput screening in the ToxCast Program and TSCA Data Needs
Citation:
Paul-Friedman, K., S. Padilla, AND Tim Shafer. High-throughput screening in the ToxCast Program and TSCA Data Needs. Presented at Office of Chemical Safety and Pollution Prevention (OCSPP) Visit to RTP June 2018, RTP, NC, June 08, 2018. https://doi.org/10.23645/epacomptox.6991118
Impact/Purpose:
Poster presentation to the EPA Office of Chemical Safety and Pollution Prevention (OCSPP) June 2018
Description:
Because of thousands of chemicals which lack any information on neurotoxic potential, the EPA has been working on screening approaches to characterizing potential neurotoxicity (filling gaps). The focus has been to develop high-throughput methods that reliably and rapidly detect alterations in processes relevant to nervous system function & development. The ToxCast Data Pipeline is being used to perform initial concentration-response analysis in a reproducible and clear manner and store all of the information at each level of analysis in a uniform way to enable consistent access to data. Data from all levels of the pipeline goes to a database, Invitrodb. From here, additional analyses (e.g., multidimensional analyses) can be performed and the results stored for reproducibility and access.
URLs/Downloads:
DOI: High-throughput screening in the ToxCast Program and TSCA Data Needs
POSTER_OCSPP_TOXCAST_DATA_JUNE2018_V5.PDF (PDF, NA pp, 1282.958 KB, about PDF)