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A Flexible Web-Interface for Integrating Multiple Data Streams in Support of Risk Prioritization of Environmental Chemicals
Grulke, Chris, A. Williams, R. Judson, AND R. Thomas. A Flexible Web-Interface for Integrating Multiple Data Streams in Support of Risk Prioritization of Environmental Chemicals. Presented at ACS, New Orleans, LA, March 18 - 22, 2018. https://doi.org/10.23645/epacomptox.6986996
This abstract for a presentation at the 2018 ACS Spring meeting is intended to report how a web interface is being built to provide flexible access to data important for risk assessment and prioritization. This interface will be layered, providing flexibility in how the different data can be aggregated, weighted, and scored when evaluating a chemical to meet the needs of multiple use scenarios.
Detailed chemical risk assessments are time-consuming and difficult to compile, leading to regulatory mandates to prioritize chemicals for further assessment. Multiple regulatory bodies (EPA, ECHA, Health Canada) are currently tasked with prioritizing chemicals for data collection and risk assessments due to the large number of chemicals in commerce or the environment for which detailed risk assessments have never been performed. Ideally, the incompletely assessed chemicals posing the highest exposure and hazard risk would be given the highest priority for a high-level risk assessment process. We have developed a web-based application that enables a rapid, flexible and transparent prioritization process. This system is built in keeping with our overarching software development methodology supporting multiple “building blocks” on top of the data-housing infrastructure and, therefore, delivers prioritizations based on the same data streams that are already available in the EPA CompTox Chemistry Dashboard. Several methods for prioritization are included in the software, including a method intended to approximate the process used to develop the 2014 TSCA Workplan List, an extension of that method that integrates alternative hazard and exposure estimates (such as POD values estimated from in vitro assay data and predicted exposure values from EPA’s SEEM model), and a method that calculates hazard-exposure ratios based on the data available. The tool has been designed to facilitate the inclusion of additional data streams as they become available within the EPA data infrastructure. Method settings are exportable to document the prioritization process and share configurations between users. The use of the tool is illustrated by prioritizing chemicals related to TSCA and the Safer Choice Ingredient List using multiple data streams related to human and ecological hazard, exposure, and physicochemical properties (persistence and bioaccumulation). This abstract does not necessarily represent U.S. EPA policy.
CGRULKE_PRIORITIZATION_POSTER.PDF (PDF,NA pp, 470.01 KB, about PDF)
Record Details:Record Type: DOCUMENT (PRESENTATION/POSTER)
Organization:U.S. ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF RESEARCH AND DEVELOPMENT
NATIONAL CENTER FOR COMPUTATIONAL TOXICOLOGY