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Computational Embryology: Agent-Based Modeling and Simulation of External Genital Development
Citation:
Knudsen, T. Computational Embryology: Agent-Based Modeling and Simulation of External Genital Development. Presented at NIH-NIDDK/American Urological Association Workshop, Linthicum, MD, May 31 - June 01, 2018. https://doi.org/10.23645/epacomptox.6953021
Impact/Purpose:
Presentation given at NIH-National Institute of Diabetes and Digestive and Kidney Diseases/American Urological Association Workshop May 2018
Description:
Presentation of the US EPA's Virtual Tissue Model project using agent-based models (ABMs). ABMs can execute simulations that self-organize cells into high levels of biological structure and function (emergent phenotypes), and simulate perturbations in the system-dose or stage response, critical pathways, or non-chemical stressors. They can also make a probabilistic rendering of where, when and how a developmental defect might occur (mechanistic interpretation).
URLs/Downloads:
DOI: Computational Embryology: Agent-Based Modeling and Simulation of External Genital Development
AUA_KNUDSEN_2018_M.PDF (PDF, NA pp, 18659.505 KB, about PDF)