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Concentration-Response Screening of Environmental Chemicals for In Vitro Point-of-Departure Determination using a Targeted RNA-Seq Whole Transcriptome Assay
Citation:
Harrill, J., I. Shah, Woodrow Setzer, C. Willis, D. Haggard, R. Judson, AND R. Thomas. Concentration-Response Screening of Environmental Chemicals for In Vitro Point-of-Departure Determination using a Targeted RNA-Seq Whole Transcriptome Assay. Society for Laboratory Automation and Screening Conference, San Diego,CA, February 03 - 07, 2018. https://doi.org/10.23645/epacomptox.6950033
Impact/Purpose:
Poster presentation at Society for Laboratory Automation and Screening Conference February 2018
Description:
Current initiatives in environmental toxicology include integrating toxicity testing data from in vitro and alternative methods into risk assessment practices. Previously, in vitro point-of-departure (PODs) estimates suitable for use in screening-level risk assessments have been based on panels of in vitro assays that report a limited number of endpoints and that may not provide comprehensive coverage of all biological pathways. Increasing efficiency and declining cost of generating whole transcriptome profiles has made high-throughput transcriptomics (HTTr) a practical option for determining in vitro bioactivity thresholds and increasing coverage of biological space in chemical screening.
URLs/Downloads:
DOI: Concentration-Response Screening of Environmental Chemicals for In Vitro Point-of-Departure Determination using a Targeted RNA-Seq Whole Transcriptome Assay
SLAS.HTTR_POSTER.V1.PDF (PDF, NA pp, 652.866 KB, about PDF)