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Development of a Human Thyroid Microtissue Model for Evaluation of Thyroid Hormone Synthesis
Citation:
Deisenroth, C., V. Soldatow, C. Brinkman, E. LeCluyse, AND R. Thomas. Development of a Human Thyroid Microtissue Model for Evaluation of Thyroid Hormone Synthesis. Presented at U.S EPA Science to Achieve Results (STAR) Organotypic Culture Models (OCM) Progress Review, RTP, NC, May 22 - 23, 2018. https://doi.org/10.23645/epacomptox.6945647
Impact/Purpose:
Poster presentation at U.S EPA 3rd Annual Science to Achieve Results (STAR) Organotypic Culture Models (OCM) Progress Review Meeting May 2018
Description:
Inhibition of key molecular initiating events in the thyroid gland such as Thyroid Stimulating Hormone Receptor (TSHR), Thyroperoxidase (TPO), and the Sodium Iodide Symporter (NIS) lead to decreased serum thyroxine (T4) levels, resulting in adverse neurodevelopmental outcomes in mammals. An assay that evaluates the function of these targets in an integrated functional model is required to evaluate chemical hazards identified in high-throughput screening platforms. This poster shows development of an in vitro organotypic culture model for evaluating disruption of thyroid hormone synthesis in the human thyroid gland.
URLs/Downloads:
DOI: Development of a Human Thyroid Microtissue Model for Evaluation of Thyroid Hormone Synthesis
5-14-18_DEISENROTH_STAR OCM_THYROID OCM_POSTER_V2_FINAL.PDF (PDF, NA pp, 1299.187 KB, about PDF)