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Moving Towards an Integrated Alternative Testing Paradigm to Identify Carcinogenic Hazards
Citation:
Thomas, R. Moving Towards an Integrated Alternative Testing Paradigm to Identify Carcinogenic Hazards. Presented at The Toxicology Forum, Washington, DC, January 29 - 31, 2018. https://doi.org/10.23645/epacomptox.6863846
Impact/Purpose:
Presentation at The Toxicology Forum Winter Meeting January 2018 on the limitations in predicting cancer hazards
Description:
The prediction of cancer hazard is confounded by limited data in relevant species. Using rodent cancer bioassay data as a benchmark is confounded by significant cross-species differences, temporal dependence, and limited reproducibility. Mechanistic approaches that use machine learning and simple assay count methods have shown little promise to predict cancer hazard. Limitations in current in vitro assays related to cancer mechanisms are being addressed e.g., metabolic competence. Estimating protective doses based on relevant biological activity may provide a feasible path forward for application to cancer risk assessment.
URLs/Downloads:
DOI: Moving Towards an Integrated Alternative Testing Paradigm to Identify Carcinogenic Hazards
HT ALTERNATIVES AND CANCER_TOXFORUM_JANUARY_2018_V3.PDF (PDF, NA pp, 3364.15 KB, about PDF)