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Chemical Priority Setting in the 21st Century
Citation:
Wambaugh, J. Chemical Priority Setting in the 21st Century. Presented at Boston University Risk Assessment Course, Boston, MA, November 09, 2017. https://doi.org/10.23645/epacomptox.6856256
Impact/Purpose:
This is a webinar lecture to a class at Boston University on Risk Assessment. The lecture focuses on how CSS Rapid Exposure and Dosimetry research may inform chemical priority setting for both TSCA and EDSP. The lecture reviews high throughput methods for bioactivity, exposure, and toxicokinetics.
Description:
We would like to know more about the risk posed by thousands of chemicals in the environment – which ones should we start with? High throughput screening (HTS) provides a path forward for identifying potential hazard. Exposure and dosimetry provide real world context to hazards indicated by HTS. Using high throughput exposure approaches we can make coarse predictions of exposure. Expanded monitoring data (exposure surveillance) allows evaluation of model predictions. Are chemicals missing that we predicted would be there? Are there unexpected chemicals? Using in vitro methods developed for pharmaceuticals, we can relatively efficiently predict toxicokinetics (TK) for large numbers of chemicals, but we are limited by analytical chemistry. All data being made public: R package “httk”: https://CRAN.R-project.org/package=httk The Chemistry Dashboard (A “Google” for chemicals) http://comptox.epa.gov/ Consumer Product Database: http://actor.epa.gov/cpcat/
URLs/Downloads:
DOI: Chemical Priority Setting in the 21st Century
EPA-CHEMICALRISK-WAMBAUGH-BU-110917.PDF (PDF, NA pp, 3922.143 KB, about PDF)