You are here:
Generating Exposure-Relevant Measurement Data for Potential Use in Support of TSCA Requirements
Citation:
Wambaugh, J., J. Sobus, A. Williams, X. Liu, M. Strynar, Chris Grulke, A. Richard, E. Ulrich, S. Newton, K. Phillips, K. Isaacs, C. Sonich-Mullin, J. Orme-Zavaleta, R. Thomas, C. Bevington, AND C. Fehrenbacher. Generating Exposure-Relevant Measurement Data for Potential Use in Support of TSCA Requirements. International Society of Exposure Science, Morrisville,NC, October 15 - 19, 2017.
Impact/Purpose:
This is a presentation on ORD research that may be of use to new efforts for TSCA prioritization. This will be presented at the International Society of Exposure Science annual meeting in October 2017 during a session on "Challenges and Opportunities: Assessing Exposures to Chemical Substances under Amended TSCA Methods, Models, and Data".
Description:
The EPA Office of Research and Development (ORD) has a number of ongoing projects which generate exposure measurements. These data may inform ongoing implementation of the amended Toxic Substances Control Act (TSCA). Exposure measurements include physical-chemical property information, monitoring (environmental, biological, and consumer product), and emission testing data. Together, these data will help identify and characterize exposure potential for chemical substances and mixtures. ORD has recently developed the Computational Toxicology (CompTox) Chemistry Dashboard for dissemination of high-quality curated chemical structures, physicochemical properties, and exposure-related data. The CompTox Chemistry dashboard includes measured and predicted properties for over 700,000 chemicals. ORD is augmenting the data with new measured values for potentially challenging chemical classes. Further, data for many chemicals in consumer products, human serum, house dust, drinking water, and other environmental media are being generated by both ORD and contract laboratories to help refine exposure pathways and reduce uncertainty in exposure predictions. Suspect screening and non-targeted analyses (SSA/NTA) using high resolution mass spectrometry methods are being used with targeted confirmation for high-priority chemicals. Finally, both ORD and contract laboratories are generating data describing the emission and migration characteristics of chemicals from consumer products using testing chamber methods. Prior to any implementation, the fitness-for-purpose of these data (e.g., for prioritization, scoping, or risk evaluation) must be evaluated in the context of TSCA requirements. The views expressed here are those of the authors and do not necessarily reflect the views or policies of the U. S. EPA.
URLs/Downloads:
TSCA_OPPT_SYMPOSIUM_ABSTRACT_FINAL_042617-2.PDF (PDF, NA pp, 113.102 KB, about PDF)ISES2017-NEWDATARELEVANTTOTSCA-101217_FINAL.PDF (PDF, NA pp, 1803.247 KB, about PDF)