Citation:

Conley, J., C. Lambright, N. Evans, E. MedlockKakaley, M. Cardon, V. Wilson, AND E. Gray. Phthalate induced urogenital abnormalities: Is PPARa activation the mechanism of action, or not? Duke Multidisciplinary Benign Urology Research Day 2018, Durham, North Carolina, May 11, 2018.

Impact/Purpose:

One aspect of our current research has been investigating PPAR activation as a potential mechanism for inducing the phthalate syndrome of male reproductive defects in laboratory rats. Additionally, there is a high level of national and international interest in the toxicological effects of per- and polyfluoroalkyl substances (PFAS) due to their widespread environmental occurrence and potential for human exposure. The majority of PFAS studied to-date activate PPAR signaling pathways and thus, could be expected to produce phthalate-like defects in male offspring. Here, we utilized the PPAR active PFAS compound, GenX, to determine if this putative molecular mechanism is able to produce phthalate-like male reproductive defects following in utero exposure. We further report on dose-responsive perinatal toxicity observed from gestational GenX exposure.

Description:

This is an abstract to be submitted for the Multidisciplinary Benign Urology Research Day 2018 at Duke University for consideration for poster or platform presentation. A significant portion of this one day meeting focuses on the linkages between male urogenital defects and exposures to environmental chemicals, including phthalates. We were contacted by the meeting organizers and encouraged to submit an abstract due to the relevance of our work to the topic.

Record Details: