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Mixtures of "anti-androgens" at low concentrations produce reproductive tract malformations in the male rat
Citation:
Conley, J. Mixtures of "anti-androgens" at low concentrations produce reproductive tract malformations in the male rat. NCSU Toxicology Program, Raleigh, NC, February 06, 2018.
Impact/Purpose:
This presentation is an invited seminar in the Toxicology Program at NC State University as part of their weekly seminar series. Our lab interrogates male reproductive toxicity via multiple molecular initiating events and this presentation highlights our work with compounds that modulate both androgen receptor and peroxisome proliferator activated receptor signaling.
Description:
No abstract was generated for this presentation as it was an invited seminar at an academic institution. Overall, the studies to be presented here focus on the ability of chemicals that modulate androgen receptor signaling via multiple molecular initiating events to act in a dose additive fashion to produce adverse effects at low individual doses. Further, our work interrogates the PPAR pathway for effects on reproductive development and our most recent work has included the environmentally-relevant compound, GenX which is a PPAR agonist and produces associated effects in the liver at high doses.