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Investigating chemical-microbiota interactions in zebrafish
Citation:
Tal, T. Investigating chemical-microbiota interactions in zebrafish. Comp Tox, rtp, Nc, April 26, 2018.
Impact/Purpose:
Intestinal microbes play important roles in development. It has been proposed that microbiota, through bioactivation or detoxification, may mediate the developmental toxicity of environmental chemicals. This work describes an experimental system comprised of colonized and microbe-free zebrafish. Using this system, we show that microbes are required for neurobehavioral development. This work also shows that exposure to bisphenol A, bisphenol F, and bisphenol S, the three least overtly toxic bisphenol chemicals identified in our study, results in significant concentration-dependent disruption of microbiota structure. In a triclosan case study, we show that microbes function to increase uptake of the parent chemical. In a 17 beta-estradiol case study, this work shows that exposure does not alter microbiota structure but dose cause hypoactivity in colonized but not microbe-free zebrafish. Collectively, this work supports the concept that microbiota modify the toxicokinetics and toxicodynamics of environmental chemicals.
Description:
no abstract needed for comptox seminar.