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Disposition and Mechanisms of Toxicities of Metals and Metalloids
Citation:
Hughes, M. Disposition and Mechanisms of Toxicities of Metals and Metalloids. Society of Toxicology, Baltimore, Maryland, March 12 - 16, 2017.
Impact/Purpose:
This presentation will increase the knowledge of the at-large toxicology community on: 1) how metals and metalloids are absorbed, distributed, metabolized and eliminated from the body; 2) the biochemical, molecular, genetic and epigenetic mechanisms that render metals and metalloids toxic. The intent is for the attendees to become more familiar with toxicological aspects of metals and metalloids so that they themselves can for example, conduct or understand experimental studies in mechanistic toxicology or more confidently review documents, regulations, etc., in this arena.
Description:
Dr. Hughes will provide a concise overview of general disposition (e.g., absorption) and mechanisms of toxicity of metal toxicity (e.g., direct interaction with functional groups of critical proteins, generation of reactive oxygen species, and alteration of cell signaling pathway) and integrating these factors on the impact of metals on epigenetics and cancer stem cells.