Development of a Neurovascular Unit Organotypic Systems Model
Citation:
Schwab, A. AND S. Hunter. Development of a Neurovascular Unit Organotypic Systems Model. Keystone Organs- and Tissues-on-Chips, Montana, Montana, April 08 - 12, 2018.
Impact/Purpose:
The focus of this poster presentation will be on the development of a human experimental model system for studying the impact of chemical-induced thyroid hormone disruption on neural morphogenesis. Thyroid hormone disruption is a major concern for children's health as there are many morphological effects produced by disruption of the thyroid hormone axis during human brain development. This project focuses on neurovascular unit (NVU) morphogenesis as a target of thyroid hormone disruption. A 2-compartment microfluidic bioreactor and a transwell system will be established to evaluate the consequences of altered thyroid hormone availability during critical neurodevelopmental periods. This cutting edge human system will be a valuable tool to bio-mimic the human NVU and allow the establishment of a quantitative relationship between altered thyroid hormone levels and neuromorphogenesis. Ultimately, this system will be essential in translating chemical effects on thyroid hormone availability and neural morphogenesis.
Description:
Abstract for poster presentation, poster and powerpoint presentation