Science Inventory

AOP-DB Frontend: A user interface for the Adverse Outcome Pathways Database.

Citation:

Langley, P., E. Kazymova, B. Vallanat, AND H. Mortensen. AOP-DB Frontend: A user interface for the Adverse Outcome Pathways Database. Society of Toxicology, San Antonio, TX, March 11 - 15, 2018.

Impact/Purpose:

The purpose of this work is to create an internal user interface for the Adverse Outcome Database (AOP-DB), an internal EPA database that aggregates association relationships between AOPs, genes, chemicals, diseases, pathways, species orthology information, ontologies. This framework will also be applied to frontend development for the NaKnowBase.

Description:

The EPA Adverse Outcome Pathway Database (AOP-DB) is a database resource that aggregates association relationships between AOPs, genes, chemicals, diseases, pathways, species orthology information, ontologies. The AOP-DB frontend is a simple yet powerful AOP-DB user interface in the form of a web application. By replacing applications like MySQL Workbench and the MySQL command line interface (MySQL CLI), it allows users to interact with the SQL database conveniently within their preferred web browser on any operating system. This approach includes all information the AOP-DB has to offer without the need of excess applications or knowledge of creating SQL queries. The frontend itself is built using pure-JavaScript frameworks Node.js and AngularJS. These modern frameworks allow for increased modularity, responsiveness, and robust page features without impacting development time. Currently, the AOP-DB frontend is to be utilized for exclusive in-house EPA use (intranet); though this is the case, the frontend is being built with eventual public external (internet) use in mind by taking appropriate measures for administration and security. Alongside these considerations, the application will also serve as a framework for other databases housed at the EPA. One database inheriting the frontend framework is the EPA Nanomaterials Research Database (NaKnowBase), a database responsible for organizing physical and chemical parameters of nanomaterials and their potential actions on environmental and biological systems. The workflow described here includes a finished mockup for the AOP-DB, a prototype that includes essential features such as database navigation, and site administration. This abstract does not reflect EPA Policy

Record Details:

Record Type: DOCUMENT (PRESENTATION/POSTER)
Product Published Date: 03/12/2018
Record Last Revised: 06/05/2018
OMB Category: Other
Record ID: 340999

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LABORATORY

ASSOCIATE DIRECTOR FOR HEALTH

RESEARCH CORES UNIT