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CRISPR and piRNAs: Fundamental Mechanisms and Key Applications of the Next Generation of Molecular Technologies in the Field of Toxicology
Citation:
McCullough, S. CRISPR and piRNAs: Fundamental Mechanisms and Key Applications of the Next Generation of Molecular Technologies in the Field of Toxicology. Society of Toxicology (SOT) Annual Meeting, San Antonio, TX, March 12 - 15, 2018.
Impact/Purpose:
This presentation will set the stage for the session by describing the similarities and differences between the molecular mechanisms utilized by these transformative tools, discussing their potential within the field of toxicology, and demonstrating their applications in revising biology
Description:
" Exploration into the roles of genes, the proteins that they encode, and the functions that they carry out within the cell is a founding pillar in the field of toxicology. Recent breakthroughs in clustered, regularly interspaced, short palindromic repeat (CRISPR) technology and PIWI-interacting RNAs (piRNAs) have resulted in the development of novel approaches to selectively modify both the genome and the epigenome. The application of these technologies will fundamentally revolutionize the development of highly sophisticated genetic and epigenetic models using human cells to examine causal relationships between specific genetic polymorphisms and epigenetic modifications at discrete loci with toxic exposure effects and susceptibility. This presentation will set the stage for the session by describing the similarities and differences between the molecular mechanisms utilized by these transformative tools, discussing their potential within the field of toxicology, and demonstrating their applications in revising biology