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Navigating through the minefield of read-across: from research to practical tools (WC10)
Citation:
Patlewicz, G., G. Helman, P. Pradeep, AND I. Shah. Navigating through the minefield of read-across: from research to practical tools (WC10). Presented at 10th World Congress on Alternatives and Animal Use in the Life Sciences, WA, Seattle, August 20 - 24, 2017.
Impact/Purpose:
Presentation at 10th World Congress on Alternatives and Animal Use in the Life Sciences
Description:
Read-across is used for regulatory purposes as a data gap filling technique. Research efforts have focused on the scientific justification and documentation challenges involved in read-across predictions. Software tools have also been developed to facilitate read-across prediction. We highlight a handful of the publicly available category workflow read-across tools to articulate their respective capabilities. Whilst these tools address a number of the workflow steps, few consider an uncertainty assessment. We will present an algorithmic, automated read-across approach using in vitro bioactivity data (from EPA’s ToxCast program) and chemical descriptor information to predict in vivo toxicity effects. We will demonstrate how read-across predictions can be evaluated to quantify uncertainty. We showcase progress in translating these efforts into practical tools. The abstract does not reflect EPA policy.
URLs/Downloads:
READ-ACROSS_GENRA_PLATFORM_CLEAN_WC_PATLEWICZ.PDF (PDF, NA pp, 75.941 KB, about PDF)PATLEWICZ_WC2018_150817_JC.PDF (PDF, NA pp, 1093.416 KB, about PDF)