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Harvesting the Promise of AOPs: An assessment and recommendations
Citation:
Carusi, A., M. Davies, G. De Grandis, B. Escher, G. Hodges, K. Leung, M. Whelan, C. Willett, AND G. Ankley. Harvesting the Promise of AOPs: An assessment and recommendations. SCIENCE OF THE TOTAL ENVIRONMENT. Elsevier BV, AMSTERDAM, Netherlands, 628:1542-1556, (2018).
Impact/Purpose:
The adverse outcome pathway (AOP) concept was developed specifically to serve as a knowledge assembly and communication tool to facilitate the transparent translation of mechanistic information into outcomes meaningful to the regulatory assessment of chemicals. However, as the AOP framework has evolved, it has become recognized that the potential stakeholder community for the concept and associated knowledge is broader than scientists and regulators directly involved in chemical safety assessment. For example, the tractability of AOP-based approaches for addressing biomedical challenges has become increasingly evident. In this paper we identify those stakeholders who currentlyor in the futurec ould benefit from the application of the AOP framework and knowledge to specific problems, and suggest strategies to engage these stakeholders more effectively. In addition, we describe and provide recommendations to meet critical needs to ensure further progression of the AOP framework as a useful, sustainable and dependable tool for chemical-effect assessment for both human health and the environment.
Description:
The adverse outcome pathway (AOP) concept was developed specifically to serve as a knowledge assembly and communication tool to facilitate the transparent translation of mechanistic information into outcomes meaningful to the regulatory assessment of chemicals. However, as the AOP framework has evolved, it has become recognized that the potential stakeholder community for the concept and associated knowledge is broader than scientists and regulators directly involved in chemical safety assessment. For example, the tractability of AOP-based approaches for addressing biomedical challenges has become increasingly evident.
