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High Throughput PBPK: Evaluating EPA's Open-Source Data and Tools for Dosimetry and Exposure Reconstruction (SOT)
Citation:
Wambaugh, J. High Throughput PBPK: Evaluating EPA's Open-Source Data and Tools for Dosimetry and Exposure Reconstruction (SOT). Presented at SOT National Meeting, Baltimore, MD, March 12 - 16, 2017. https://doi.org/10.23645/epacomptox.5084269
Impact/Purpose:
Presentation at SOT annual meeting on new technologies and in vitro testing approaches that have been valuable additions to risk assessments that have historically relied solely on in vivo test results. Compared to in vivo methods, in vitro high throughput screening (HTS) assays are less expensive, faster and can provide mechanistic insights on chemical action.
Description:
To address this need, new tools have been created for characterizing, simulating, and evaluating chemical biokinetics. Physiologically-based pharmacokinetic (PBPK) models provide estimates of chemical exposures that produce potentially hazardous tissue concentrations, while tissue microdosimetry PK models relate whole-body chemical exposures to cell-scale concentrations.
URLs/Downloads:
DOI: High Throughput PBPK: Evaluating EPA's Open-Source Data and Tools for Dosimetry and Exposure Reconstruction (SOT)
WAMBAUGH_SOT_ABSTRACT_STRAWMAN_HTPBPK.PDF (PDF, NA pp, 44.87 KB, about PDF)
WAMBAUGH_SOT_SLIDES_HTTKEVAL-2_FINAL.PDF (PDF, NA pp, 1558.063 KB, about PDF)