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Towards Building an AOP-based Prenatal Developmental Toxicity Ontology (CEFIC LRI Workshop - Brussels)
Citation:
Staal, Y., N. Baker, L. Burgoon, G. Daston, T. Knudsen, AND A. Piersma. Towards Building an AOP-based Prenatal Developmental Toxicity Ontology (CEFIC LRI Workshop - Brussels). Presented at CEFIC LRI Workshop, Brussels, N/A, BELGIUM, November 16 - 17, 2016. https://doi.org/10.23645/epacomptox.5181304
Impact/Purpose:
Poster to be presented at Cefic Longrange Initiative workshop in Brussels, Nov 16-17 2016. This poster introduces the developmental ontology project.
Description:
Ontologies are a way to formalize domain-specific scientific knowledge. A developmental ontology would help researchers describe the pathways and processes critical to embryonic development and provide a way to link their chemical disruption to adverse outcomes. Designing one for developmental toxicology is scientific challenging, given the complexity of embryogenesis and the continuous changes at the molecular, cellular, tissue and organ levels occurring in time and location throughout gestation. Our aim is to explore the construction of an ontology that integrates biological targets of toxicity with chemical structure-activity information and developmental trajectories by focusing on one important pathway as a prototype. We decided to start from the perspective of retinoic acid (RA), which is a morphogen that regulates embryonic growth and differentiation and a known human teratogen.Retinoid signaling includes elements in retinoid metabolism (e.g., RALDH, CYP26) and nuclear receptor (RAR, RXR) activation and thus serves as an excellent prototype for adverse outcome pathway (AOP) elucidation associated with developmental defects such as caudal regression.
URLs/Downloads:
DOI: Towards Building an AOP-based Prenatal Developmental Toxicity Ontology (CEFIC LRI Workshop - Brussels)
POSTER CEFIC LRI WORKSHOP NOV2016_CLEARED.PDF (PDF, NA pp, 297.011 KB, about PDF)