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Virtual Embryo: Cell-Agent Based Modeling of Developmental Processes and Toxicities (CSS BOSC)
Knudsen, T., K. Saili, T. Zurlinden, R. Spencer, N. Baker, AND S. Hutson. Virtual Embryo: Cell-Agent Based Modeling of Developmental Processes and Toxicities (CSS BOSC). Presented at CSS BOSC, RTP, NC, November 16 - 18, 2016. https://doi.org/10.23645/epacomptox.5181148
This poster will be presented at the CSS BOSC meeting, November 16-18, 2017 for discussion on the Virtual Tissue Models project (CSS 17.02), tasks 1, 2 and 4.
Spatial regulation of cellular dynamics is fundamental to morphological development. As such, chemical disruption of spatial dynamics is a determinant of developmental toxicity. Incorporating spatial dynamics into AOPs for developmental toxicity is desired but constrained by the lack of a suitable computational environment for in silico embryogenesis. EPA’s ‘Virtual Embryo’ provides a heuristic platform that translates in vitro data from ToxCast bioactivity profiles into probabilities of a predicted adverse outcome. Models delivered to date include angiogenesis, urethrogenesis, palatogenesis, and limb outgrowth. Models under development include neurovascular development and heart development. Design, development and implementation of a Virtual Tissue Laboratory System infrastucture will enable high-performance computing and engage translation. These biologically-relevant in silico models translate mechanistic information generated at a basic level of research (ToxCast) into recognizable phenotypes (cybermorphs) predicted at a higher level. Systems represented dynamically bring AOPs to ‘life,’ which in a Children’s Environmental Health setting can be used for mechanism-specific developmental toxicity as part of an Integrated Testing Strategy for rapid screening purposes. (Disclaimer: this poster does not reflect EPA policy).
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BOSC_VTM_POSTER_A_M.PDF (PDF, NA pp, 2202.037 KB, about PDF)