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Leveraging Publicly-Available Consumer Product and Chemical Data in Support of Exposure Modeling
Citation:
Isaacs, K., K. Dionisio, K. Phillips, AND P. Price. Leveraging Publicly-Available Consumer Product and Chemical Data in Support of Exposure Modeling. 2017 Annual Meeting of the Society for Risk Analysis, Arlington, Virginia, December 10 - 14, 2017.
Impact/Purpose:
This presentation describes the development of new consumer product chemical databases for support of exposure and risk evaluations.
Description:
Near-field contact with chemicals in consumer products has been identified as a significant source of human exposure. To predict such exposures, information about chemical occurrence in consumer products is required, but is often not available. The Chemicals and Products Database (CPDat) has been developed by the U.S. EPA’s Chemical Safety and Sustainability research program in an attempt to fill these data gaps using information from publicly-available sources. CPDat currently includes qualitative and quantitative information on reported product ingredients from Material Safety Data Sheets and published ingredient lists. In addition, the database contains results of new predictive models for chemical function and product chemical weight fractions. The consumer products included in the database have been mapped to over 300 product use categories (PUCs) that allow linkage to consumer use (i.e. habits and practices) data. CPDat has been integrated with the U.S. EPA’s Computational Toxicology Dashboard (https://comptox.epa.gov/dashboard), which allows for linking of the specific product information in CPDat (e.g. ingredient, weight fraction, PUC) with chemical-specific information (e.g. structure, property) available through the Dashboard. These data and linkages allow for the parameterization of EPA’s human exposure models for thousands of chemicals in consumer products. Future refinements to CPDat will include addition of data obtained via targeted or non-targeted analyses of consumer products. As the database grows, it will increase our ability to characterize chemicals in consumer products and articles rapidly and defensibly for use in exposure and risk evaluations.
