Science Inventory

Characterizing Risks of Exposures to Combined Stressors: An Overview

Citation:

Rice, G. Characterizing Risks of Exposures to Combined Stressors: An Overview. SOciety of Risk Analysis Annual Meeting, Arlington, VA, December 10 - 14, 2017.

Impact/Purpose:

This is a presentation within a workshop on Cumulative Risk Assessment (CRA). The workshop is being presented at the Society of Risk Analysis Annual Meeting in Arlington, VA on December 10, 2017.

Description:

Cumulative risk assessment (CRA) addresses the impacts of multiple chemical and nonchemical stressors on communities, resulting from complex exposures for populations with a variety of vulnerabilities. These efforts focus on real world exposure scenarios and applications that range from environmental justice and community sustainability to population health promotion and protection. Nonchemical stressors include biological and physical agents (e.g., microbes and noise) as well as socioeconomic stressors and psychosocial conditions (e.g., associated with natural disasters). Public concerns that can initiate CRAs include (1) elevated environmental measurements or biomonitoring data; (2) multiple sources of pollutants or stressors; and (3) changes in disease rates or patterns (e.g., leukemia cluster) or ecological effects (e.g., loss of wildlife diversity). This workshop focuses on human health and begins with an overview of three CRA elements: analysis, characterization, and quantification (as feasible) of the combined risks from multiple stressors. Teaching methods include lectures and hands-on exercises. Presentations highlight basic concepts, methods, and resources for conducting a population-based CRA. A central theme is integrating exposure and dose-response information with population characteristics during planning and scoping based on initiating factors. Vulnerability factors are also addressed including socioeconomic status, lifestyle and behavioral factors (e.g. diet/nutritional status), psychosocial stress, as well as susceptibility due to immutable factors (e.g. race, age, genetics). Methods for estimating human health risks are discussed and applied, including epidemiologic approaches and assessing the joint toxicity of chemical mixtures. In the exercises, participants develop chemical and non-chemical stressor groups using exposure and toxicity factors, link them with population vulnerability factors and conduct a cumulative risk characterization.

URLs/Downloads:

CUME RISK COURSE RISK CHARACTERIZATION RICE 11-17-17 FOR CLEARANCE.PPTX

Record Details:

Record Type: DOCUMENT (PRESENTATION/SLIDE)
Product Published Date: 11/29/2017
Record Last Revised: 11/30/2017
OMB Category: Other
Record ID: 338535

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL CENTER FOR ENVIRONMENTAL ASSESSMENT

CINCINNATI OH

CHEMICAL RISK ASSESSMENT BRANCH