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Teratology Talk: Complex mixtures of anti-androgens at concentrations below individual chemical effect levels produces reproductive tract malformations in the male rat
Citation:
Conley, J., C. Lambright, N. Evans, M. Cardon, E. MedlockKakaley, V. Wilson, AND E. Gray. Teratology Talk: Complex mixtures of anti-androgens at concentrations below individual chemical effect levels produces reproductive tract malformations in the male rat. Teratology Society, Denver, CO, June 24 - 28, 2017.
Impact/Purpose:
This work provides a demonstration of the utility of an adverse outcome pathway network for anti-androgenic effects in male rats. We observed effects at very low individual doses of chemicals in a complex mixture that included multiple molecular initiating events. This data is useful for informing the risk assessment process and provides and example of cumulative mixture effects. Further it advances the development and knowledgebase of AOPs.
Description:
This is an abstract to be submitted to the Teratology Society for consideration of inclusion in the upcoming 2017 meeting.