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SOT Talk: A mixture of 18 anti-androgens at concentrations below individual chemical effect levels produces reproductive tract malformations in the male rat
Citation:
Conley, J., C. Lambright, N. Evans, M. Cardon, E. MedlockKakaley, V. Wilson, AND E. Gray. SOT Talk: A mixture of 18 anti-androgens at concentrations below individual chemical effect levels produces reproductive tract malformations in the male rat. Society of Toxicology Annual Meeting, MD, Baltimore, March 12 - 16, 2017.
Impact/Purpose:
This abstract describes research on a mixture of anti-androgenic chemicals with variable molecular initiating events at low individual doses. Overall, the work supports the hypothesis that a mixture of chemicals that act on a common biological pathway can produce dose additive effects even when each chemical in the mixture is at or below a no observed effect level (NOEL).
Description:
This product is a conference abstract being submitted for the 2017 Society of Toxicology meeting in Baltimore.