Citation:

Conley, J., C. Lambright, N. Evans, M. Cardon, V. Wilson, AND E. Gray. A mixture of 18 anti-androgens at concentrations below individual chemical effect levels produces reproductive tract malformations in the male rat. North Carolina Society of Toxicology, Research Triangle Park, NC, October 25, 2016.

Impact/Purpose:

The purpose of this research was to investigate the interaction of orally administered anti-androgenic chemicals with varying molecular initiating events in a mixture and whether the effects of these chemicals more accurately modeled by dose addition or response addition. Further we were interested in informing the risk assessment process in regard to the additive effects of low doses of compounds that act on a common developmental pathway.

Description:

This product is a regional conference abstract and award application. The abstract primarily serves as the application for the NCSOT PARC Award and secondarily as a poster abstract for the fall meeting of NCSOT at NIEHS.

Record Details: