Active vs. sedentary lifestyle from weaning to adulthood and susceptibility to ozone in rats
Citation:
Gordon, C., P. Phillips, A. Ledbetter, S. Snow, M. Schladweiler, A. Johnstone, AND U. Kodavanti. Active vs. sedentary lifestyle from weaning to adulthood and susceptibility to ozone in rats. INHALATION TOXICOLOGY. Informa Healthcare USA, New York, NY, 312(1):L100-L109, (2017).
Impact/Purpose:
This study addresses the role of a sedentary lifestyle initiated in childhood on the susceptibility to ozone in adults. Post-weaned, 22 day old rats were used as an animal model and were either allowed to live a sedentary lifestyle until reaching adulthood or were given continuous access to a running wheel. Rats with running wheels will run several kilometers per night and have less body fat and improved glucose tolerance compared to sedentary animals. The major findings of this study was that a sedentary lifestyle was associated with an exacerbation in ozone-induced production of eosinophils in the lungs, suggesting an increased risk to asthma. Sedentary animals also exhibited impaired glucose tolerance in response to ozone. Overall, the animal model used in this study suggests that early exposure to exercise in children may lead to improved physiological responses to air pollution as adults. Moreover, a sedentary lifestyle in early childhood, especially when combined with a calorically rich diet, may exacerbate the cardiopulmonary responses to ozone in adulthood.
Description:
This is publication for a peer review journal.
