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Realizing the promise of AOPs: A stakeholder-driven roadmap to the future
Citation:
Ankley, G., A. Carusi, M. Davies, G. De Grandis, B. Escher, G. Hodges, K. Leung, M. Whelan, AND C. Willett. Realizing the promise of AOPs: A stakeholder-driven roadmap to the future. SETAC North America, Minneapolis, MN, November 12 - 16, 2017.
Impact/Purpose:
MED has been a leader in the development of the adverse outcome pathway (AOP) concept to support chemical safety assessments for human health and the environment. This presentation is from a 2017 Pellston workshop (sponsored by the Society of Environmental Toxicology and Chemistry) focused on the development and use of AOPs. The talk specifically will address the identification of stakeholders utilizing the AOP framework, and consider how these stakeholders can contribute to a sustainable model to endure the viability of AOPs in the future.
Description:
The adverse outcome pathway (AOP) framework was developed to serve as a knowledge assembly and communication tool to facilitate translation of mechanistic (e.g., molecular, biochemical, histological) data into adverse apical outcomes meaningful to chemical risk assessment. Although initially designed for ecotoxicology applications, the framework has also received extensive attention relative to chemical safety assessments for human health. Moreover, as the AOP concept and associated knowledgebases have evolved, it has become recognized that the potential stakeholder community is broader than scientists and regulators directly involved in chemical safety assessment. For example, the application of AOP-based thinking for addressing biomedical challenges has become increasingly evident. This presentation will identify various stakeholders who currently, or could potentially, benefit from application of the AOP framework and knowledge to specific needs, and describes collaboration strategies to effectively engage these stakeholders, including how to maintain a viable, sustainable network to support AOP stakeholders. We make recommendations as to how to address the governance and coordination of AOP development and knowledge dissemination in a multi-stakeholder consortium, as well as what the requirements are for ensuring stable financial resourcing for key infrastructure.