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Peer Review for EPA’s Proposed Approaches to Inform the Derivation of a Maximum Contaminant Level Goal for Perchlorate in Drinking Water
Citation:
Peer Review for EPA’s Proposed Approaches to Inform the Derivation of a Maximum Contaminant Level Goal for Perchlorate in Drinking Water. U.S. Environmental Protection Agency, Washington, D.C.
Impact/Purpose:
The purpose of this review is to seek guidance from expert peer review on the scientific assessment that links the revised perchlorate BBDR model predictions to neurodevelopmental effects in children to inform decision-making for perchlorate under the Safe Drinking Water Act. The outcome of this peer review is not the derivation of an MCLG; rather, it is to solicit expert comment on the proposed approaches that might be used to inform future decisions on the derivation of an MCLG.
Description:
EPA is developing approaches to inform the derivation of a Maximum Contaminant Level Goal (MCLG) for perchlorate in drinking water under the Safe Drinking Water Act. EPA previously conducted an independent, external, scientific peer review of the draft biologically-based dose-response (BBDR; also known as a PBPK/PD) model and report titled BBDR Models for the Effect of Perchlorate on Thyroid Hormones in the Infant, Breast Feeding Mother, Pregnant Mother, and Fetus: Model Development, Revision, and Preliminary Dose-Response Analyses. The model predicts the relationship between perchlorate exposure and thyroid hormone levels in sensitive life stages and has been revised based on peer reviewer recommendations. EPA considered all of the peer reviewers’ recommendations and focused on those that were anticipated to be most important for increasing the scientific rigor of the model and modeling results.
URLs/Downloads:
Peer Review Report - Perchlorate MCLG Approach
Final Perchlorate MCLG Approach Peer Review Charge Questions (PDF, NA pp, 189 KB, about PDF)