EPA Science Inventory

Sample Processing Approach for Detection of Ricin in Surface Samples

Citation:

Shah, S., S. Kane, A. Erler, AND T. Alfaro. Sample Processing Approach for Detection of Ricin in Surface Samples . JOURNAL OF IMMUNOLOGICAL METHODS. Elsevier Science Ltd, New York, NY, , 9, (2017).

Description:

Journal Article

Purpose/Objective:

Several Ricin Bioterrorism incidents have occurred since 9/11 terrorist attacks. During those incidents environmental samples including surface samples were analyzed during both the pre- and post-decontamination phases of response. However, no sample processing protocol was used for sample cleanup to avoid false results. This manuscript includes the research work on the first ever sample processing protocol development for environmental samples containing Ricin biotoxin. This protocol not only removes some of the aqueous-phase soluble interferences of analytical method but also concentrates Ricin up to 30-fold. Therefore, this protocol will help in greatly reducing analytical method interferences and improving the method limit of detection enabling detection of low concentration of Ricin in environmental samples. (The detailed final report on this research effort was cleared and approved for publication through STICS. A subset of the data from that report is included in this journal article.)

URLs/Downloads:

SAMPLE PROCESSING APPROACH FOR DETECTION OF RICIN IN SURFACE SAMPLES   Exit

Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Start Date: 08/30/2017
Completion Date: 08/30/2017
Record Last Revised: 11/14/2017
Record Created: 09/28/2017
Record Released: 09/28/2017
OMB Category: Other
Record ID: 337750

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL HOMELAND SECURITY RESEARCH CENTER

THREAT AND CONSEQUENCE ASSESSMENT DIVISION