You are here:
A New Tox21 Strategic Plan and the Integration of EPA Science
Citation:
Thomas, R. A New Tox21 Strategic Plan and the Integration of EPA Science. Presented at 10th World Congress on Alternatives and Animal Use in the Life Sciences, Seattle, WA, August 20 - 24, 2017.
Impact/Purpose:
presentation at the 10th World Congress on Alternatives and Animal Use in the Life Sciences on a New Tox21 Strategic Plan and the Integration of EPA Science
Description:
The predominant focus of Tox21 collaboration has been on developing and applying high-throughput in vitro screening to hazard identification and dose-response. To remain relevant, the interagency collaboration must broaden its focus to developing new predictive toxicology testing approaches for the 21st century. The first part of the talk will outline the new Tox21 strategic plan and common goals of the collaboration. The second part of the talk will focus on evolution of the EPA research program and its integration with the Tox21 collaboration. For EPA, the expanded research activities includes significant investments in cheminformatics and computational chemistry, a multi-pronged approach to hazard characterization and prediction, continued improvements in toxicokinetic and exposure modeling, and increased focus on characterizing uncertainty and variability. This abstract does not necessarily reflect U.S. EPA policy.