EPA announced the release of the draft IRIS Assessment Plan for Chloroform for public comment. This document was discussed at an EPA Science Advisory Board (SAB) Chemical Assessment Advisory Committee (CAAC) meeting on September 27-28, 2017. Information regarding the meeting can be found on the SAB website.

Citation:

U.S. EPA. IRIS Assessment Plan for Chloroform (Scoping and Problem Formulation Materials). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-17/330, 2017.

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This document presents a draft assessment plan for chloroform that will be the subject of an SAB/Chemical Assessment Advisory Committee meeting in September 2017 and that will define the scope and approach of the IRIS assessment for chloroform.

Description:

In September 2017, EPA released the draft IRIS Assessment Plan (IAP) for Chloroform for public review and comment. An IRIS Assessment Plan (IAP) communicates to the public the plan for assessing each individual chemical and includes summary information on the IRIS Program’s scoping and initial problem formulation; objectives and specific aims for the assessment; the PECO (Populations, Exposures, Comparators, and Outcomes) criteria that outlines the evidence considered most pertinent to the assessment; and identification of key areas of scientific complexity. The PECO provides the framework for developing literature search strategies and inclusion/exclusion criteria, particularly with respect to evidence stream (i.e., human, animal, mechanistic), exposure measures and outcome measures.

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