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IRIS Assessment Plan for Ethylbenzene (Scoping and Problem Formulation Materials)
Citation:
U.S. EPA. IRIS Assessment Plan for Ethylbenzene (Scoping and Problem Formulation Materials). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-17/332, 2017.
Impact/Purpose:
This document presents a draft assessment plan for ethylbenzene that will be the subject of an SAB/Chemical Assessment Advisory Committee meeting in September 2017 and that will define the scope and approach of the IRIS assessment for ethylbenzene.
Description:
In September 2017, EPA released the draft IRIS Assessment Plan (IAP) for Ethylbenzene for public review and comment. An IRIS Assessment Plan (IAP) communicates to the public the plan for assessing each individual chemical and includes summary information on the IRIS Program’s scoping and initial problem formulation; objectives and specific aims for the assessment; the PECO (Populations, Exposures, Comparators, and Outcomes) criteria that outlines the evidence considered most pertinent to the assessment; and identification of key areas of scientific complexity. The PECO provides the framework for developing literature search strategies and inclusion/exclusion criteria, particularly with respect to evidence stream (i.e., human, animal, mechanistic), exposure measures and outcome measures.
URLs/Downloads:
IRIS Assessment Plan for Ethylbenzene (PDF, 17 pp, 354 KB, about PDF)EPA-HQ-ORD-2014-0526
HERO Project Page: Ethylbenzene (Sep 2017)
SAB Activity Page on the Briefing by NCEA on development of IRIS draft assessments
Memorandum: SAB Chemical Assessment Advisory Committee Briefing on the Integrated Risk Information System (IRIS) Evolution of Assessment Practices (PDF, 4 pp, 181 KB, about PDF)
FR Notice: Sep 18, 2017