Citation:

Bartrand, T., H. Marks, M. Coleman, D. Donahue, S. Hines, J. Comer, AND S. Taft. Modeling Rabbit Responses to Single and Multiple Aerosol Exposures of Bacillus anthracis Spores (HS 4.04.02 - 475). RISK ANALYSIS. Blackwell Publishing, Malden, MA, 37(5):943-957, (2017).

Impact/Purpose:

Bacillus anthracis, the causative agent of inhalation anthrax, is one of the most highly studied biological threat agents, yet consensus is still lacking on an appropriate dose-response relationship to describe human health effects from low doses and multiple exposures. Dose-response relationships can be an important element in the development of protective actions and decontamination strategies after a release of a biological threat agent. This work describes novel methodologies to help predict dose-response relationships for low and multiple doses of Bacillus anthracis spores in the rabbit model of inhalation anthrax. The models developed in the paper can be used to develop approaches for other human pathogens. Anyone involved in the identification of environmental concentrations where protective actions may be necessary such as local and state public health agencies, environmental unit leaders, and risk assessors.

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Journal Article

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