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Toxicological Tipping Points and Cell Stress (SOT 2016 Symposium Discriminating between adaptation and adversity))
Citation:
Shah, I. Toxicological Tipping Points and Cell Stress (SOT 2016 Symposium Discriminating between adaptation and adversity)). Presented at Society of Toxicology Annual meeting, New Orleans, LA, March 13 - 17, 2016. https://doi.org/10.23645/epacomptox.5084227
Impact/Purpose:
Presentation at an SOT symposium co-chaired by the presenter on Toxicological Tipping Points and Cell Stress determinations using High Content Imaging.
Description:
This symposium will bring together cutting-edge ideas on HCI as alternative testing paradigm for predictive toxicology and will focus on: 1) innovative tools for interrogating the molecular and cellular state of cells; 2) evaluating sentinel stress response pathways that can profile the chemical-induced perturbations in cells; 3) using HCI responses to analyze the balance between cellular injury and recovery through homeostatic mechanisms; 4) computational tools for systems-level analysis of chemical concentration and time-dependent effects to identify “tipping points” in system recovery; and 5) the application of HCI data in predicting DILI. This symposium will address these issues in a series of highly focused presentations on 21st century toxicology using HCI as an innovative tool for information risk assessment, and for estimating points of departure for risk assessment.
URLs/Downloads:
DOI: Toxicological Tipping Points and Cell Stress (SOT 2016 Symposium Discriminating between adaptation and adversity))
SHAH-SOT-2016-CELL-STRESS-WKSHP-V1.PDF (PDF, NA pp, 2101.245 KB, about PDF)
IMRAN SOT-2016-HCI-SYMP-PROPOSAL-V2.3_PRESENTATION_ABSTRACT.PDF (PDF, NA pp, 36.097 KB, about PDF)