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Building Scientific Confidence in the Development and Evaluation of Read-Across Using Tox21 Approaches (SOT Annual Meeting)
Citation:
Patlewicz, G. AND I. Shah. Building Scientific Confidence in the Development and Evaluation of Read-Across Using Tox21 Approaches (SOT Annual Meeting). Presented at SOT 2016, New Orleans, LA, March 13 - 17, 2016. https://doi.org/10.23645/epacomptox.5084155
Impact/Purpose:
Slide or platform presentation at the SOT 2016 annual meeting. This is an proof of concept evaluation for a handful of regulatory categories to determine whether there is any added value of considering bioactivity data to substantiate an existing category rationale.
Description:
Acceptance of read-across is an ongoing challenge and several efforts are underway to identify and address major uncertainties associated with read-across. Several approaches have been proposed but to date few case studies if any have evaluated how Tox21 approaches may be instructive in substantiating category rationales, or indeed their associated read-across justifications. Here we have identified a handful of former OECD HPV categories and evaluated to what extent data from HTS assays notably that generated through ToxCast are helpful in strengthening the rationale underlying those categories and their associated read-across. A handful of categories were identified based on the overlap between the HPV chemicals and the ToxCast inventory. Those selected included the ethylene glycols and primary aliphatic alcohols categories. The findings so far are mixed, highlighting the importance of carefully interpreting the ToxCast data in its appropriate context.
URLs/Downloads:
DOI: Building Scientific Confidence in the Development and Evaluation of Read-Across Using Tox21 Approaches (SOT Annual Meeting)
SOT_PRESENTATION_READ-ACROSS_PATLEWICZ_FINAL.PDF (PDF, NA pp, 3144.558 KB, about PDF)
SOT_2016_PATLEWICZ_ABSTRACT.PDF (PDF, NA pp, 92.605 KB, about PDF)