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Reverse Toxicokinetics: From In Vitro Concentration to In Vivo Dose
Citation:
Wetmore, B. Reverse Toxicokinetics: From In Vitro Concentration to In Vivo Dose. Singapore International Water Week Convention "Hot Issues" Workshop, Singapore, SINGAPORE, July 10 - 14, 2016.
Impact/Purpose:
The National Exposure Research Laboratory (NERL) Computational Exposure Division (CED) develops and evaluates data, decision-support tools, and models to be applied to media-specific or receptor-specific problem areas. CED uses modeling-based approaches to characterize exposures, evaluate fate and transport, and support environmental diagnostics/forensics with input from multiple data sources. It also develops media- and receptor-specific models, process models, and decision support tools for use both within and outside of EPA.
Description:
This talk provided an update to an international audience about the state of the science to relate results from high-throughput bioactivity screening efforts out to an external exposure that would be required to achieve blood concentrations at which these bioactivities may be observed. This in vitro-in vivo extrapolation approach was described, with examples of how this information could be used in risk-based prioritization. Recent efforts were also described, including triage strategies that make use of the vast amount of in vitro data now available to predict chemical toxicokinetics, as well as an approach that incorporates in vitro and in silico tools to predict toxicokinetics in sensitive populations (e.g., children).
