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Intergrating in Vitro and In Silico Approaches to Assess Inter-individual Toxicokinetic Variability
Citation:
Wetmore, B. Intergrating in Vitro and In Silico Approaches to Assess Inter-individual Toxicokinetic Variability. Continuing Education Symposium, Human Safety Chapter of the Biofusion - Procter & Gamble, Cincinnati, OH, June 08, 2016.
Impact/Purpose:
The National Exposure Research Laboratory (NERL) Computational Exposure Division (CED) develops and evaluates data, decision-support tools, and models to be applied to media-specific or receptor-specific problem areas. CED uses modeling-based approaches to characterize exposures, evaluate fate and transport, and support environmental diagnostics/forensics with input from multiple data sources. It also develops media- and receptor-specific models, process models, and decision support tools for use both within and outside of EPA.
Description:
This educational talk provided an introduction to what is currently known to contribute to differences in how various populations and life stages metabolize chemicals to which they are exposed. These differences will impact how different populations may be affected following chemical exposures. In addition, examples of how this information is utilized in chemical and drug safety research are discussed, along with an update on a research approach that integrates vitro and in silico tools to quantitate this variability for application in chemical safety efforts.