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Emerging Approaches and Opportunities to inform Internal Dosimetry and Inter-individual Variability
Citation:
Wetmore, B. Emerging Approaches and Opportunities to inform Internal Dosimetry and Inter-individual Variability. PBPK Summit, Washington, DC, August 11, 2016.
Impact/Purpose:
The National Exposure Research Laboratory (NERL) Computational Exposure Division (CED) develops and evaluates data, decision-support tools, and models to be applied to media-specific or receptor-specific problem areas. CED uses modeling-based approaches to characterize exposures, evaluate fate and transport, and support environmental diagnostics/forensics with input from multiple data sources. It also develops media- and receptor-specific models, process models, and decision support tools for use both within and outside of EPA.
Description:
This talk provided an update to EPA ORD scientists and program officers about planned research within the Chemical Safety for Sustainability program to address chemical toxicokinetics and strategies to understand better the range of variability across different populations and life stages. The talk covered current knowledge of contributors to toxicokinetic variability, availability of experimental and modeling tools to measure the extent of this variability, and additional research and information needs that will support further efforts to refine and advance these approaches.