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Advances in EPA’s Rapid Exposure and Dosimetry Project (Interagency Alternatives Assessment Webinar)
Citation:
Isaacs, K. AND J. Wambaugh. Advances in EPA’s Rapid Exposure and Dosimetry Project (Interagency Alternatives Assessment Webinar). Interagency Alternatives Assessment Webinar, NA, NC, February 25, 2016. https://doi.org/10.23645/epacomptox.5067667
Impact/Purpose:
This is a presentation given as part of the Interagency Alternatives Assessment webinar series.
Description:
Estimates of human and ecological exposures are required as critical input to risk-based prioritization and screening of chemicals. The CSS Rapid Exposure and Dosimetry project seeks to develop the data, tools, and evaluation approaches required to generate rapid and scientifically-defensible exposure predictions for the full universe of existing and proposed commercial chemicals. Efforts in this project include: development of mechanistic and empirical models of human and ecological exposures, identification or generation of new high-throughput exposure data (e.g., chemical use or property information, consumer product use data, and consumer product and article chemical compositions, and ecological/biological monitoring data), and development of innovative statistical techniques for evaluating exposure predictions against available monitoring data. In addition, the project seeks to develop the scientific approaches required to relate bioactive concentrations identified in the ToxCast project to predicted real world doses (i.e. in vitro-in vivo extrapolation). Rapid prediction of chemical exposure and bioactive doses allows prioritization based upon risk of adverse outcomes due to environmental chemical exposure.
URLs/Downloads:
DOI: Advances in EPA’s Rapid Exposure and Dosimetry Project (Interagency Alternatives Assessment Webinar)
EPA-ADVANCESINEPASRAPIDEXPOSUREANDDOSIMETRYPROJECT PPTX.PDF (PDF, NA pp, 3103.841 KB, about PDF)