EPA Science Inventory

Prioritization of pesticides based on daily dietary exposure potential as determined from the SHEDS model

Citation:

Melnyk, L., Z. Wang, Z. Li, AND J. Xue. Prioritization of pesticides based on daily dietary exposure potential as determined from the SHEDS model. FOOD AND CHEMICAL TOXICOLOGY. Elsevier Science Ltd, New York, NY, 96:167-173, (2016).

Description:

A major pathway for exposure to many pesticides is through diet. The objectives were to rank pesticides by comparing their calculated daily dietary exposure as determined by EPA's Stochastic Human Exposure and Dose Simulation (SHEDS) to single pesticides for different age groups to acceptable daily intakes (ADI), characterize pesticide trends in exposures over different time periods, and determine commodities contributing to pesticide exposures. SHEDS was applied, using Pesticide Data Program (PDP) (1991–2011) and pesticide usage data on crops from USDA combined with NHANES dietary consumption data, to generate exposure estimates by age group. ADI data collected from EPA, WHO, and other sources were used to rank pesticides based on relativeness of the dietary exposure potential to ADI by age groups. Sensitivity analysis provided trends in pesticide exposures. Within SHEDS, commodities contributing the majority of pesticides with greatest exposure potential were determined. The results indicated that the highest ranking pesticides were methamidophos and diazinon which exceeded 100% of the ADI. Sensitivity analysis indicated that exposure to methamidophos, diazinon, malathion, ethion and formetanate hydrochloride had a marked decrease from 1991–1999 to 2000–2011. Contributions analysis indicated that apples, mushroom, carrots, and lettuce contributed to diazinon exposure. Beans and pepper contributed to methamidophos exposure.

Purpose/Objective:

A journal article presenting pesticide rankings by risk potential that may lead to strategic mitigation decisions.

URLs/Downloads:

http://www.sciencedirect.com/science/article/pii/S0278691516302459   Exit

Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Completion Date: 10/01/2016
Record Last Revised: 08/26/2016
Record Created: 08/26/2016
Record Released: 08/26/2016
OMB Category: Other
Record ID: 325330

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL EXPOSURE RESEARCH LAB

SYSTEMS EXPOSURE DIVISION

ENVIRONMENTAL FUTURES ANALYSIS BRANCH