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Percutaneous Penetration of Chemicals and Aging Skin
Citation:
Hughes, M. Percutaneous Penetration of Chemicals and Aging Skin. Textbook of Aging Skin. Springer Berlin - Heidelberg, , Germany, , 771-780, (2016).
Impact/Purpose:
This a book chapter for the second edition of the book, Textbook of Aging Skin. I wrote a chapter for the first edition and the editors invited me to contribute to the second edition. There has been some suggestions that as a person ages, dermal absorption of chemicals also changes. This is due in part to the evident changes in skin as one ages (wrinkles, damage from sun, etc.). The chapter describes changes in skin as a person ages. I also included data from experiments that examined the effect of age on dermal absorption using animal models and humans. While there may be some chemical specific changes in dermal absorption with age, there is no one general trend (either increase or decrease) for this effect. Why was it done? The percentage of the elderly population is increasing at least in the United States. With people living longer, public health officials need to recognize the same exposure results still exist: oral, pulmonary and dermal. Absorption of chemicals may change in the elderly population compared to younger populations, and this needs to be considered by the public health officials. What is the impact to the field and Agency? While there is no apparent trend in change in dermal absorption of chemicals as a person ages, the field and Agency need to recognize that such a change could occur when conducting risk assessments of chemicals in the elderly population.
Description:
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