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Adaptation of the Conditions of U.S. EPA Method 538 for the Analysis of Nerve Agent VX (EA2192) in Water by Direct Aqueous Injection- Liquid Chromatography/Tandem Mass Spectrometry
Citation:
U.S. EPA. Adaptation of the Conditions of U.S. EPA Method 538 for the Analysis of Nerve Agent VX (EA2192) in Water by Direct Aqueous Injection- Liquid Chromatography/Tandem Mass Spectrometry . U.S. Environmental Protection Agency, Washington, DC, EPA/600/R-15/097, 2016.
Impact/Purpose:
The objective of this study was to evaluate U.S. EPA’s Method 538 for the assessment of drinking water exposure to the nerve agent degradation product, EA2192, the most toxic degradation product of nerve agent VX. As a result of the similarities in sample preparation and analysis that Method 538 uses for nonvolatile chemicals, this method is applicable to the nonvolatile Chemical Warfare Agent (CWA) degradation product, EA2192, in drinking water. The method may be applicable to other nonvolatile CWAs and their respective degradation products as well, but the method will need extensive testing to verify compatibility. Gaps associated with the need for analysis methods capable of analyzing such analytes were addressed by adapting the EPA 538 method for this CWA degradation product. Many laboratories have the experience and capability to run the already rigorous method for nonvolatile compounds in drinking water. Increasing the number of laboratories capable of carrying out these methods serves to significantly increase the surge laboratory capacity to address sample throughput during a large exposure event. The approach desired for this study was to start with a proven high performance liquid chromatography tandem mass spectrometry (HPLC/MS/MS) method for nonvolatile chemicals in drinking water and assess the inclusion of a similar nonvolatile chemical, EA2192.
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