EPA Science Inventory

Accelerating Adverse Outcome Pathway Development Using Publicly Available Data Sources

Citation:

Oki, N., M. Nelms, S. Bell, H. Mortensen, AND S. Edwards. Accelerating Adverse Outcome Pathway Development Using Publicly Available Data Sources. Current Environmental Health Reports. Springer International Publishing AG, Cham (ZG), Switzerland, , 1-11, (2016).

Description:

The adverse outcome pathway (AOP) concept links molecular perturbations with organism and population-level outcomes to support high-throughput toxicity testing. International efforts are underway to define AOPs and store the information supporting these AOPs in a central knowledgebase, however, this process is currently labor-intensive and time-consuming. Publicly available data sources provide a wealth of information that could be used to define computationally-predicted AOPs (cpAOPs), which could serve as a basis for creating expert-derived AOPs in a much more efficient way. Computational tools for mining large datasets provide the means for extracting and organizing the information captured in these public data sources. Using cpAOPs as a starting point for expert-derived AOPs should accelerate AOP development. Coupling this with tools to coordinate and facilitate the expert development efforts will increase the number and quality of AOPs produced, which should play a key role in advancing the adoption of twenty-first century toxicity testing strategies.

Purpose/Objective:

This review article describes how effective knowledge management and automated approaches to AOP development can enhance and accelerate the development and use of AOPs. As the principles documented in this review are put into practice, we anticipate that the quality and quantity of AOPs available will increase substantially. This, in turn, will aid in the interpretation of ToxCast and other high-throughput toxicity testing efforts.

URLs/Downloads:

https://doi.org/10.1007/s40572-016-0079-y   Exit

Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Completion Date: 01/25/2016
Record Last Revised: 11/22/2017
Record Created: 02/18/2016
Record Released: 02/18/2016
OMB Category: Other
Record ID: 311223

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LABORATORY

INTEGRATED SYSTEMS TOXICOLOGY DIVISION